Human Fallopian Tubes Express Prostacyclin (PGI) Synthase and Cyclooxygenases and Synthesize Abundant PGI
نویسندگان
چکیده
منابع مشابه
Retinoic acid induces PGI synthase expression in human endothelial cells.
Retinoic acid (RA) exhibits anti-inflammatory, anti-tumor, and immuno-modulatory actions, and affects angiogenesis and thrombosis. Arachidonic acid (AA) metabolites are involved in all these processes. We explored the effect of RA on AA metabolism in human umbilical vein endothelial cells (HUVECs). 13-cis-RA increased the release of prostaglandin I(2) (PGI(2)), both spontaneous and thrombin-ind...
متن کاملEndothelial prostacyclin (PGI-2) production of human and porcine valve allografts related to ischemic history.
BACKGROUND The significance of cellular viability in human valve allografts for functional clinical longevity continues to be debated. Meaningful tests for this biological entity are therefore in demand to quantify the relative merits of graft origin and procurement techniques. The valve leaflet endothelium is recognized as a particularly sensitive target to noxes and its continued ability to p...
متن کاملProstacyclin ( Prostaglandin 12 , PGI 2 ) Inhibits Platelet Adhesion and Thrombus Formation on Subendothelium
Prostaglandin I2 (prostacyclin, PGI2), a subadhesion and thrombus formation on subenstance synthesized in the wall of blood dothelium was inhibited in blood containing vessels, has been previously shown to inhibit 10 nM PGI2. PGI2 appears to reduce adhesion the aggregation of platelets in Stirred plateby inhibiting platelet spreading. These findlet-rich plasma. We used a method in which ings su...
متن کاملProstacyclin ( Prostaglandin 12 , PGI 2 ) Inhibits Platelet Adhesion and Thrombus Formation on
Prostaglandin I2 (prostacyclin, PGI2), a subadhesion and thrombus formation on subenstance synthesized in the wall of blood dothelium was inhibited in blood containing vessels, has been previously shown to inhibit 10 nM PGI2. PGI2 appears to reduce adhesion the aggregation of platelets in Stirred plateby inhibiting platelet spreading. These findlet-rich plasma. We used a method in which ings su...
متن کاملHDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling.
OBJECTIVE In endothelial cells, cyclooxygenase-1 (COX-1) and COX-2 both contribute to prostacyclin production. Recent findings suggest that COX-2 contributes significantly to systemic prostacyclin synthesis in humans; whether COX-2 inhibition is related to an increased cardiovascular risk is undergoing debate. HDLs have been shown to increase prostacyclin synthesis, thus in the present study we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2002
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2002-020199